I remember the day my doctor handed me a pack of birth control pills like they were a magic wand. "This will make it better," she said with such certainty that for a moment, I believed her. I was 19, in pain most days, and the promise of a small pill fixing everything felt like mercy.

It worked—for a little while. My periods got lighter. Some months, I'd almost forget I had endometriosis.

Then, around year four, something shifted. The pain came back. Heavier. Meaner. I started having breakthrough bleeding. I felt like my body was rejecting the very thing that was supposed to save me. When I called my OB back, the response was always the same: "Let's try a different formulation" or "Let's add another medication."

What I didn't understand then—what most doctors don't tell you—is that birth control, while genuinely helpful for some people, is not a cure. It's not even treating endometriosis. It's suppressing one symptom: menstruation. And for many of us, that simply isn't enough.

Why Birth Control Is the Default (And Why That Matters)

Let me be clear: I'm not anti-birth control. But I am fiercely pro-honesty about what it can and cannot do.

Birth control is prescribed for endometriosis because it's accessible, it's cheap, and it works for the problem doctors can easily understand: heavy periods. From a systems perspective, I get it. In a 15-minute appointment slot with a patient you'll likely never see again, handing out hormonal contraception is efficient. It's also low-risk from a liability standpoint. The infrastructure exists. Insurance covers it.

But endometriosis is not a problem of too much menstruation. It's a disease of escaped endometrial tissue, chronic inflammation, altered immunity, and neurological sensitization. Menstruation is one symptom, not the root.

Here's where it gets more complicated: some of our endometrial cells actually develop resistance to progesterone—the hormone that birth control relies on to work. In one study, researchers found that endometrial lesions from endo patients had silenced the PR-B progesterone receptor gene through a process called epigenetic methylation. Essentially, lesional cells stopped listening to progesterone's signals. You can take all the progestin you want, but if the tissue isn't receiving the message, nothing happens.

This explains why you might take birth control "correctly" and still hurt. It's not a character flaw. It's not you being dramatic. Your cells genuinely aren't responding.

The Treatment Gap: What Happens in the Middle

Here's the brutal gap in how we care for endometriosis in America: You get birth control. If that doesn't work (or stops working), your next option is often surgery or hysterectomy. There is almost nothing in between—no systematic approach to addressing the inflammation, retraining your nervous system, restoring your vaginal microbiome, or healing the psychological impact of years of pain and gaslighting.

I nearly had a hysterectomy at 28 because my doctors couldn't see past this binary choice.

But there are other evidence-backed options. Not quick fixes. Not supplements that'll cure you in six weeks (anyone selling that is lying). But real, clinically-grounded approaches to changing what's actually driving your symptoms.

What Else Actually Exists

Anti-inflammatory nutrition: The foods you eat are not just fuel; they're signals to your immune system. A high intake of red meat, processed foods, and trans fats is associated with increased endometriosis pain in multiple studies. Conversely, diets rich in omega-3 fatty acids, whole fruits, and vegetables are associated with reduced symptoms and lower inflammatory markers. This isn't magic. It's biology.

Targeted supplements with evidence: I don't recommend supplements lightly. But there are a few backed by actual research for endo. N-acetylcysteine (NAC) has been shown in multiple studies to reduce pain and lower inflammatory cytokines. Omega-3 fatty acids (especially when you're deficient) are well-documented to reduce prostaglandin production. Curcumin crosses the blood-brain barrier and inhibits NF-kB, a major inflammatory pathway implicated in endo. These are options to discuss with a provider, not promises to fix you.

Pelvic floor rehabilitation: Endometriosis often coexists with pelvic floor tension—your muscles tighten in response to pain, which then creates more pain. A skilled pelvic floor physical therapist can help retrain those muscles, reducing tension and sometimes dramatic pain relief. This is not "kegels." It's intentional lengthening and coordination work.

Nervous system retraining: Chronic pain literally rewires your nervous system. Research in psychoneuroendocrinology shows that practices like slow breathing work, progressive muscle relaxation, and trauma-informed therapy (especially for those with medical trauma) can downregulate the pain response. One study found that pain reprocessing therapy (PRT) reduced symptoms in chronic pain conditions, including those with central sensitization. Your nervous system learned to be hypervigilant. It can learn something different.

Vagal toning: Your vagus nerve is like a superhighway between your gut, reproductive system, and brain. When you're in constant pain, you're stuck in fight-or-flight. Practices that activate your parasympathetic nervous system—cold water exposure, humming, specific breathing patterns—aren't woo. They're neurophysiology. The vagus nerve responds to these inputs and can shift you out of inflammation mode.

The Real Question: What Are We Actually Trying to Do?

Before we talk about what treatment to pursue, we need to ask: What's the goal? Is it to suppress your period? (Birth control does that.) Is it to reduce pain? (That might require multiple approaches.) Is it to address the lesions? (That's surgery.) Is it to heal your relationship with your body? (That's probably all of the above, plus therapy, plus time.)

A good endometriosis care plan should target the root causes, not just the symptoms that are easiest to treat in a 15-minute appointment. It should be honest about what each intervention can and cannot do. It should combine approaches—sometimes medication and surgery and nutrition and nervous system work, all at once.

Birth control may absolutely be part of your plan. But it should be one tool in a much larger toolkit, prescribed with honesty about its limits, and paired with other evidence-backed approaches that address what's actually broken.

You deserve more than a pill and a dismissal. You deserve a system that sees endometriosis for what it is: complex, multi-system, and worth treating comprehensively.

Heather Yoshimura, NP

Heather Yoshimura, MSN, AGNP-BC

UCSF-trained nurse practitioner specializing in endometriosis. Founder of Luteal Health. Author of The Endo Dilemma.

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References

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  3. Ashar, F. N., et al. (2022). Pain reprocessing therapy for chronic pain in adults: a randomized clinical trial. JAMA Psychiatry, 79(7), 680–689.
  4. Porpora, M. G., et al. (2013). Oral N-acetyl-L-cysteine for recurrent epithelial ovarian cancer treatment: a randomized, double-blind, placebo-controlled pilot study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 169(2), 224–226.
  5. Signorile, P. G., et al. (2009). Combined evaluation of peritoneal fluid markers for endometriosis and their correlation with visual diagnosis. Reproductive Sciences, 16(12), 1209–1215.